Main Page

This Wikibase contains information about toxic, safe, and potentially toxic compounds related to the VHP4Safety project. It aggregated public information about them.

A short overview and technical introduction is found in this presentation.

Alternative user interface

A simpler user interface to browse the content is found at https://kb.cloud.vhp4safety.nl/. Here, you can browse collections and look at the knowledge collected in this wiki about specific compounds.

Example Jupyter notebooks

There are two Jupyter notebooks the give two examples how to use the knowledge in this wiki in Python.

More details

Every VHP4Safety partner can get access. Email Egon Willighagen at Maastricht University.

• Hepatotoxins, including aflatoxin B1 (Q1), allyl alcohol (Q9), and amiodarone (Q17)
• Cardiotoxins, including iodoacetamide (Q34), and methotrexate (Q35)
• Renal toxins, including ochratoxin A (Q49)
• Bisphenols, including bisphenol A (Q80) (all bisphenols)
• Organophosphates, e.g. 1,2-dicaproyl-sn-phosphatidyl-L-serine (Q781) (all organophosphates)
• PFAS, e.g. 1,1,1,2,2,3,3-heptafluorobutane (Q4714) (all PFAS)

Queries

The following links are SPARQL queries, taking advantage of the FAIR-ness of this service:

• List all compounds
  • VHP4Safety subset or this query
  • ToxBank Wiki subset
  • AOP-Wiki Stressor subset
• Compound with known xenobiotic metabolism
• All compound collections

The making of

This Wikibase is populated with the help from cheminformatics tools like the Chemistry Development Kit, Bacting, and public knowledge bases like Wikidata and PubChem.

How to cite

If you cite the Compound Wiki, please cite (until further notice) this article: "The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data", ALTEX, 2025, https://doi.org/10.14573/altex.2407211

If you use the data from this Compound Wiki, please cite additionally the dataset (https://doi.org/10.5281/zenodo.14835777) or a specific, suitable version of the dataset: https://zenodo.org/records/14835777

Funding

VHP4Safety – the Virtual Human Platform for safety assessment project NWA 1292.19.272 is part of the NWA research program ‘Research along Routes by Consortia (ORC)’, which is funded by the Netherlands Organization for Scientific Research (NWO). The project started on June 1, 2021 with a budget of over 10 million Euros and will last for the duration of 5 years.